38 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28233679	2	Synthesis and biological evaluation of novel N3-substituted dihydropyrimidine derivatives as T-type calcium channel blockers and their efficacy as analgesics in mouse models of inflammatory pain.	South Dakota State University
27517811	12	Synthesis and T-type calcium channel-blocking effects of aryl(1,5-disubstituted-pyrazol-3-yl)methyl sulfonamides for neuropathic pain treatment.	Korea Institute of Science & Technology (Kist)
27933950	304	Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers.	Actelion Pharmaceuticals
27579577	91	Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers.	Actelion Pharmaceuticals
26231163	50	Discovery of novel bridged tetrahydronaphthalene derivatives as potent T/L-type calcium channel blockers.	Actelion Pharmaceuticals
26101566	14	Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639.	Abbvie
25155913	32	Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa.	Astrazeneca
23200256	54	Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor.	Astrazeneca
18160281	10	Design and SAR of selective T-type calcium channel antagonists containing a biaryl sulfonamide core.	Bristol-Myers Squibb R & D
21316226	12	Pyridyl amides as potent inhibitors of T-type calcium channels.	Merck Research Laboratories
20934333	2	Design, syntheses, and SAR of 2,8-diazaspiro[4.5]decanones as T-type calcium channel antagonists.	Icagen
20659804	19	Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity.	Ewha Womans University
20580233	82	T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.	Merck Research Laboratory
32327350	38	Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers.	Kyung Hee University
27774123	37	Discovery of AZD2716: A Novel Secreted Phospholipase A	Astrazeneca
27591007	16	Synthesis and evaluation of 6-pyrazoylamido-3N-substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain.	Korea Institute of Science & Technology (Kist)
30869888	61	Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.	TBA
30928197	13	Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model.	Korea Institute of Science and Technology
30031654	14	Design and synthesis of novel anti-hyperalgesic agents based on 6-prenylnaringenin as the T-type calcium channel blockers.	University of Toyama
29622412	64	Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels.	Iitb-Monash Research Academy
30034586	90	Design of Selective sPLA	Astrazeneca
29116786	265	Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.	Idorsia Pharmaceuticals
29074257	115	Discovery and evaluation of Ca	Idorsia Pharmaceuticals
29066309	87	Discovery and evaluation of Ca	Idorsia Pharmaceuticals
28720324	7	Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives.	Korea University of Science and Technology (Ust)
28720332	3	Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects.	Kyung Hee University
28530802	121	Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation.	Vanderbilt University Institute of Imaging Science
15831442	46	Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.	Taisho Pharmaceutical
8887981	72	A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.	Abbott Laboratories
7518514	46	(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.	Abbott Laboratories